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The use of aspirin as primary prevention in individuals with elevated lipoprotein a

The use of aspirin as primary prevention in individuals with elevated lipoprotein a

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The use of aspirin as primary prevention in individuals with elevated lipoprotein a

Lipoprotein (a) is known to be increasingly important in identifying patients at increased risk of cardiovascular (CV) events.

On the horizon, there are treatments that will reduce the production of Lp(a) levels, and hopefully, will reduce the risk of CV diseases. However, until these therapies are approved, we need to use what we currently have to protect these patients.

According to a recent study, daily use of aspirin could provide some CV protection.

The researchers used data from the Multi-Ethnic Study of Atherosclerosis. They divided the patients into those with Lp(a) levels greater than 50 mg/dL and those with Lp(a) levels less than 50 mg/dL. When they looked at CV events, the group with Lp(a) levels greater than 50 mg/dL that were on aspirin had a 46% reduction in CV events compared with those not on aspirin (HR, 0.54; 95% CI, 0.32–0.94; P = .03). For the group that had Lp(a) levels less than 50 mg/dL, no benefit was associated with being on aspirin.

For our patients with Lp(a) levels greater than 50mg/dL, we should put them on aspirin based on this study. It is also very important to maximize statin therapy to lower the cholesterol risk. We should also control their blood pressure and blood glucose levels and encourage them to quit smoking. In other words, we need to optimize everything else while we wait for these new therapies that will directly reduce Journal of the American Heart Association

Reference:
Aspirin and Cardiovascular Risk in Individuals With Elevated Lipoprotein(a): The Multi-Ethnic Study of
Atherosclerosis
J Am Heart Assoc 2024 Jan 31;[EPub Ahead of Print], HS Bhatia, P Trainor, S Carlisle, MY Tsai, MH
Criqui, A DeFilippis, S Tsimikas

Dr Yiannis Panayiotides


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Είναι αδύνατο να ξέρει την ιατρική, αυτός που δεν ξέρει ακριβώς τι είναι ο άνθρωπος. ΙΠΠΟΚΡΑΤΗΣ




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It is impossible for one to know medicine if he doesn’t know what a human being is. HIPPOCRATES






Copyright by Dr Yiannis Panayiotides 2018. All rights reserved.



Copyright by Dr Yiannis Panayiotides 2018. All rights reserved.