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Exercise Can Reduce Atrial Fibrillation Burden by 45%

For several years, both patients with Atrial Fibrillation (AF) and clinicians worried that physical activity could worsen atrial fibrillation.

However, according to the NEXAF study, which was recently presented at the European Society of Cardiology (ESC) Congress 2026, exercise proves to be highly beneficial.

The study showed that an individualized, structured physical activity program lasting 1 year reduced the overall AF burden by 45% compared to standard care. In addition, patients achieved better physical fitness and experienced a 46% reduction in AF-related hospitalizations.

Despite clear guideline recommendations, surveys show that only 1 in 10 patients is referred to an exercise-based rehabilitation program. There is a significant gap between clinical guidelines and everyday practice.

Furthermore, experts emphasize that this preventive strategy must be completely individualized, determining the exact dose and intensity of exercise required to ensure both clinical benefit and long-term compliance of the patient.

The NEXAF study proved that a hybrid model, which combines short-term supervision with long-term home-based exercise supported by digital tools, is perfectly feasible in everyday practice and requires limited personnel.

This is exactly what we aim for through our online application.

We apply evidence-based exercise protocols so you can optimize your heart health.

Try Cardiac Exercise Rx
-> https://cardiac-exercise-rx.vercel.app


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Exercise Helps the Heart and the Mind. But It Needs to Be Done Under the Right Guidance.

People with coronary artery disease don’t just face problems with their heart — anxiety and depression are much more common in this group. A large 2025 study examined 36 clinical trials and over 3,500 patients to see whether exercise helps, and whether it matters how it’s done.

The results were clear: exercise improved quality of life and significantly reduced anxiety and depression. However, these benefits were only seen when exercise was carried out under supervision and with proper guidance. Interestingly, the type of exercise (high-intensity or moderate) mattered far less than guidance, structure, and human interaction.

It is therefore very important that, after a cardiac event, exercise takes place in supervised sessions, which not only help the heart, but also meaningfully support mental health.

Reference:
Toval A, et al. Eur Heart J. 2025;46:2186–2201. doi: 10.1093/eurheartj/ehae870


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Heart Rate Variability: A Simple Clue to a Longer, Healthier Life

Every heartbeat is followed by a slightly different gap before the next one, this natural variation is called “heart rate variability” (HRV). A study published in 2020 compared young people, people in their 80s, and people over 100 years old, and found that HRV tends to be higher in younger people and lower in older people. Among the people over 100 who were followed over time, those with higher HRV tended to live longer than those with lower HRV. This suggests HRV may be a simple marker of how resilient and healthy the body is, not just a number related to the heart.

The encouraging news is that HRV isn’t fixed, and that it can be improved. Better sleep, effective stress management, and regular aerobic exercise are all known to raise HRV over time. In other words, healthy daily habits may not just make you feel better, they may genuinely support a longer, healthier life.

You don’t need a hospital visit to check your HRV anymore. Many modern smartwatches and fitness trackers can measure it easily, right from your wrist. While these consumer devices aren’t a substitute for medical evaluation, they can be a helpful, motivating way to track how your lifestyle habits are affecting your body over time.

Reference:
Hernández-Vicente A, Hernando D, Santos-Lozano A, et al. Heart Rate
Variability and Exceptional Longevity. Front Physiol. 2020;11:566399. doi:
10.3389/fphys.2020.566399


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When is a heart patient able to travel by plane?

Air travel is generally safe for most heart patients, provided that their condition is stable and managed by their doctor.

However, flight conditions (altitude, pressure, immobility) harbor specific risks that can strain the cardiovascular system.

Although the airplane cabin is pressurized, air pressure at high altitudes is lower than on the ground. This slightly reduces blood oxygen levels, forcing the heart to beat faster to cope. In individuals with coronary artery disease, heart failure, or pulmonary hypertension, this change can cause shortness of breath or angina (chest pain).

Prolonged immobility in a confined space, combined with dehydration, significantly increases the risk of blood clots forming in the legs.

The stress of travel, delays, standing in security lines, and carrying luggage release stress hormones. These can cause a sudden spike in blood pressure and heart rate, increasing the likelihood of arrhythmias or ischemic episodes.

There are specific cases where flying may be contraindicated until the patient’s condition stabilizes, such as:

  1. Recent myocardial infarction (recovery periods often range from 1 to 4 weeks depending on severity and complications).
  2. Unstable angina (chest pain that occurs even at rest).
  3. Uncontrolled heart failure.
  4. Severe, uncontrolled arrhythmias.
  5. Recent heart surgery (recovery periods often range from 4 to 6 weeks).

If a cardiologist gives their approval for the trip, patients are generally advised to follow these instructions:

  1. Proper hydration: Drink plenty of water during the flight. Strictly avoid alcohol and caffeine, as they can exacerbate dehydration and increase heart rate.
  2. Mobility: Stand up and walk in the aisle for a few minutes every 1-2 hours.
  3. Medication Management: Always keep all medications in the airplane cabin (not in checked luggage) and carry an amount greater than the intended duration of the trip.

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Can a stress test reveal Brugada syndrome?

Brugada syndrome is an inherited form of arrhythmia, in which despite the heart being structurally completely normal, dangerous arrhythmias can occur under certain conditions.

Diagnosis is typically made with the resting electrocardiogram (ECG), which detects a characteristic abnormality. However, in some cases this subtle anomaly remains hidden within the ECG. If there is a clinical suspicion, this specific ECG alteration can be unmasked using a specialized pharmacological provocation test (ajmaline challenge).

Genetic testing can also provide diagnostic support. The most common gene associated with the disease is SCN5A (responsible for 20-30% of cases).

A stress test (exercise tolerance test) is another examination that few people know can assist in establishing the diagnosis of Brugada syndrome. Specifically, in an individual with suspected Brugada syndrome and a normal resting ECG, the recovery phase of the stress test can reveal the characteristic abnormality, particularly in a supine position using "high precordial leads." The transition from exercise to rest, under conditions dominated by parasympathetic tone (vagally-induced), appears to facilitate the unmasking of concealed electrocardiographic abnormalities of the syndrome in approximately 25% of cases.

Reference:
Exercise and Exercise Stress Testing in Brugada Syndrome: Diagnostic, Prognostic, and Safety Implications
https://doi.org/10.1016/j.jacasi.2026.03.021


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Physical activity after a heart attack : how soon is safe to start

Physical activity is essential to be done regularly in patients with coronary heart disease, because it substantially reduces the risk of recurrent cardiac events.

However, most physicians recommend to initiate exercise after a month has passed after the episode.

A recent study demonstrates that patients who have had a heart attack may be able to engage in physical activity within a week after hospital discharge.

This was prospective cohort study, which enrolled 165 patients (average age 65, 65% men) who had myocardial infarction (MI). A thigh-worn accelerometer was used to monitor their activity during the first week after they were discharged.

According to the authors early post-discharge activity appears to be safe. This reinforces the idea that early mobilization and promotion of physical activity could become a more central component of post-MI care

Reference:
American Journal of Preventive Cardiology
Available online 17 April 2026, 101641
Pre- and post-discharge physical activity in acute myocardial infarction: Relation to
clinical events across 5-year follow-up


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Is it ethically and medically correct to perform an electrocardiogram (ECG) on all athletes?

Performing an electrocardiogram is a fundamental part of an athlete’s pre-participation cardiovascular evaluation. The contribution of the ECG in detecting clinically silent conditions that may predispose athletes to sudden cardiac death is decisive, as it increases detection sensitivity to over 90%.

For this reason, countries such as Cyprus, Greece, Italy, and Israel have established mandatory ECG requirements through specific legislation for those participating in official sporting events.

Last year, similar legislation was passed in the state of Florida in the United States.

This sparked some reactions from experts to such an extent that an announcement was finally issued by the American College of Cardiology (ACC). This specific announcement is co-signed by some of the major names in Sports Cardiology in America.

According to this announcement, the widespread use of electrocardiograms (ECGs) for all athletes conceals several pitfalls. A primary concern is that mass ECG screening, especially when performed by unqualified individuals, leads to a significant financial burden on the national health system.

The reckless and unnecessary referral of athletes for further imaging examinations brings not only financial but also psychological costs, as well as social stigmatization.

Adolescents and young athletes may be excluded from their teams and lose their scholarships, while their medical records are tarnished, causing serious repercussions for future employment and medical insurance.

According to the specific announcement, it appears more beneficial for public health to equip all sports venues with automated external defibrillators (AEDs) rather than performing ECGs on all athletes.

Regarding our country, the healthcare infrastructure is better and access to specialists is clearly easier compared to America. This potentially allows for the widespread performance of ECGs on athletes. However, the continuous education of doctors and their specialization in interpreting the athlete’s ECG is essential, so that the actual benefit to public health outweighs the financial, social, and psychological costs.

Reference:
JACC Journals, 13 February 2026
Authors: Jonathan H. Kim, Aaron L. Baggish, Doriane Coleman, Elizabeth H.
Dineen, Kimberly G. Harmon, Rachel Lampert, Benjamin D. Levine, and Matthew W.
Martinez
Opposing Legislative Mandates for ECG Screening in Competitive Athletes: A
Report of the American College of Cardiology Solution Set Oversight Committee


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Bradycardia in athletes: The result of training or a genetic cause

Endurance athletes often exhibit low resting heart rates as a result of excessive training.

However, according to a recent study published in Circulation there seems to be a genetic predisposition to prominent bradycardia.

The study, which included 465 endurance athletes, supports the concept that some athletes are not only trained to have low heart rates but are also genetically predisposed to them.

This research raises the possibility that being born with a genetic substrate of lower heart rate increases the likelihood of better athletic performance, without any risk of cardiovascular events.

Reference:
Circulation. Originally Published 18 December 2025
Bradycardia in Athletes: Prevalence, Mechanisms, and Risks
https://doi.org/10.1161/CIRCULATIONAHA.125.076170


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Is marathon running linked to cardiac damage?

Running has become a very common type of recreational physical activity. Many also attempt to exceed their limits by participating in long distance races, such as a marathon (42Km).

It is controversial whether this type of physical exhaustion is beneficial or harmful to the heart.

A recently published study has attempted to answer this question.

According to the study there was an acute effect, specifically on the right ventricle of the heart.

They found that right ventricular ejection fraction declined significantly (from 52.4% to 47.6%) immediately after the race. However, within 3 days systolic function of the right ventricle recovered completely.

Participants in the study (152 male runners, mean age 43) were followed up for 10 years. It was very reassuring that no effect was identified in the structure and overall function of the heart.

In general, it appears top be safe for the heart to be a marathon runner. However, caution is required after races so that enough time is provided for the heart to rest.

Reference:
Long-Term Changes in Ventricular Function in Recreational Marathon Runners.
JAMA Cardiology
Published Online: December 10, 2025
doi: 10.1001/jamacardio.2025.4456


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Atrial fibrillation after by-pass surgery (CABG) : anticoagulants or maybe not?

Atrial fibrillation is an arrhythmia that occurs commonly after by-pass surgery (CABG). It is estimated to happen in 30% of operated patients. It is often transient and normal rhythm is restored, either spontaneously or with a medical intervention.

New findings question the need for lifelong oral anticoagulants for patients who develop atrial fibrillation AF after CABG, showing that although the arrythmia may be more frequent than previously estimated, the overall burden of arrhythmia is negligible after the firs 30 days.

The study, published in JAMA, demonstrated that while nearly half of 198 patients who underwent CABG developed AF within a year of the surgery, the median burden of arrythmia events was well less than 1%.

According to the authors, it is reasonable to assess these patients about 30 days after CABG surgery with a HOLTER rhythm monitor. Depending on the overall burden of AF it can be decided whether lifelong anticoagulation therapy is needed or not.

Reference:
Long-Term Continuous Monitoring of New-Onset Atrial Fibrillation After Coronary
Artery Bypass Grafting
JAMA. Published Online: October 9, 2025



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Copyright by Dr Yiannis Panayiotides 2018. All rights reserved.



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